Associate Professor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Forensic Medicine, Sichuan University
Address: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Forensic Medicine, Sichuan University, #17, Section 3, Renmin South Road, Chengdu, P.R.China, 610044
Phone Number: (86)028-85501283
Email Address: liuhaoy@hotmail.com
Dr. Liu’s main research interests lie in the study of understanding the mechanisms of carcinogenesis. The focus of Dr. Liu’s research program is to define the effect of metabolism reprogramming in cancer development. The ongoing research project is: the role of B7-H3, an immune-regulatory protein, in the regulation of metabolism of cancer. Dr. Liu has published 18 peer reviewed papers. Most of the publications have been appeared in leading journals, including Cancer Research, Oncogene, Journal of Biological Chemistry, Nature Communication and Molecular Cancer Therapeutics.
Education and Training
Sichuan University, PhD, 2002
West China University of Medical Sciences, MS,1999
Hunan Normal University, BS,1996
Mitchell Cancer Institute, University of South Alabama, Postdoctoral Fellow, 2008-2011
Area of Interest
The role of metabolism reprogramming in cancer development
Selected Publications
1. Lim S*,Liu H*#, Madeira da Silva L, Arora R, Liu Z, Phillips JB, Schmitt DC, Vu T, McClellan S, Lin Y, Lin W, Piazza GA, Fodstad O#, Tan M#. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1a.Cancer Res. 2016;76(8);2231-42. (IF=9.122, *co-first authors,#co-corresponding authors)
2. Liu Z,Liu H, Desai S, Schmitt DC, Zhou M, Khong HT, Klos KS, McClellan S, Fodstad O, Tan M. miR-125b functions as a key mediator for snail-induced stem cell propagation and chemoresistance.J Biol Chem. 2013 Feb 8;288(6):4334-45.(IF=5.328)
3. Ding Y, Liu Z, Desai S, Zhao Y,Liu H, Pannell LK, Yi H, Wright ER, Owen LB, Dean-Colomb W, Fodstad O, LuJ, LeDoux SP, Wilson GL, Tan M.Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.Nat Commun.2012, 3: 1271. (IF=10.015)
4. Zhao Y,Liu H, Liu Z, Ding Y, LeDoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R, Liu B, Fodstad O, Chen J, Wu Y, Price JE, and Tan M. Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.Cancer Res.2011, 71(13); 4585-97. (IF = 7.856).
5. Liu H, Tekle C, Chen YW, Kristian A, Zhao YH, Zhou M, Liu ZX, Ding Y, Wang B, M?landsmo GM, Fodstad O, Tan M. B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.Mol Cancer Ther.2011, 10(6):960-71. (IF= 5.226)
6. Zhao Y*,Liu H*, Riker AI, Fodstad O, Ledoux SP, Wilson GL, Tan M. Emerging metabolic targets in cancer therapy.Front Biosci.2011, 16:1844-1860. (IF= 3.521,*co-first authors)
7. Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M. Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.Oncogene.2009, 28(42): 3689-3701. (IF= 7.135)
8. Zhou M, Zhao Y, Ding Y,Liu H, Liu Z, Fodstad O, Riker AI, Kamarajugadda S, Lu J, Owen LB, Ledoux SP, Tan M. Inhibition of lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol.Mol Cancer.2010, 9(1):33. (IF=3.779)
9. Zhou M, Liu Z, Zhao Y, Ding Y,Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI, Tan M. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic BCL-2 antagonist killer 1 (BAK1) expression.J Biol Chem.2010, 285(28):21496-21507. (IF=5.328)